Nicole De Jesus has a recent publication in Circulation Research

Nicole De Jesus, Ph.D. Candidate in Biomedical Engineering, and Ripplinger Lab colleagues have a new publication in Circulation Research titled “Optical Mapping of Sarcoplasmic Reticulum Ca2+ in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation.”

Sarcoplasmic reticulum (SR) Ca cycling is key to normal excitation-contraction coupling but also contribute to pathological cardiac alternans and arrhythmia.  Simultaneous optical mapping of SR Ca and transmembrane potential in the intact heart shows that ryanodine receptor refractoriness played a key role in the onset of SR Ca alternans and during ventricular fibrillation.  This novel method provides insight into SR Ca handling during cardiac alternans and arrhythmia.

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