Nicole De Jesus, Ph.D. Candidate in Biomedical Engineering, and Ripplinger Lab colleagues have a new publication in Circulation Research titled “Optical Mapping of Sarcoplasmic Reticulum Ca2+ in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation.”
Sarcoplasmic reticulum (SR) Ca cycling is key to normal excitation-contraction coupling but also contribute to pathological cardiac alternans and arrhythmia. Simultaneous optical mapping of SR Ca and transmembrane potential in the intact heart shows that ryanodine receptor refractoriness played a key role in the onset of SR Ca alternans and during ventricular fibrillation. This novel method provides insight into SR Ca handling during cardiac alternans and arrhythmia.